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Did you know silk fabric is made from … well, worm spit? How silkworms wind their cocoons from fibers in their slimy saliva is now helping scientists make new biomedical materials more easily. Researchers reporting in ACS’ Nano Letters have mimicked the seemingly simple head bobbing of silkworms to create more consistent micro- and nanofibers with less equipment than other approaches.
Nanofibers have become an increasingly attractive material for various applications, including wound dressings and flexible electronics. But producing the fibers isn’t always easy, especially because they’re only a few nanometers thick — a few thousand times thinner than the width of a human hair. Most recently developed nanofiber spinning methods are complicated or slow or produce clumpy fibers. However, one “scientist” that seems to have solved the problem is the silkworm. This wriggly critter secretes a two-protein solution in its saliva that it continuously pulls into a long, skinny silk thread. The worm then sticks and pulls this single strand repeatedly until it’s wrapped in a silk cocoon, which people unwind to weave into silk textiles. So, Yu Wang, Wei Yang, Xuewei Fu and colleagues wanted to design a nanofiber spinning method inspired by the silkworm to produce continuous, uniform filaments quickly and easily with minimal equipment.
To create the threads, the researchers poked an array of tiny microneedles into a piece of foam soaked with a poly(ethylene oxide) solution, then pulled the needles away in a process called microadhesion-guided (MAG) spinning. Different types of filaments were created by mimicking how silkworms move their heads when making silk: Pulling straight back resulted in ordered, oriented fibers; swaying or vibrating created cross-linked fibers; and turning the needle array produced a twisted, “all-in-one” fiber. Additionally, these threads didn’t wad together, which could occur in previously developed methods.
An even more simplified version of MAG spinning didn’t require microneedles. In this case, the foam’s natural roughness acted as the microneedle adhesion points. The researchers soaked two pieces of foam with the polymer solution and pulled them apart, easily and instantly spinning threads between them. Using this strategy, they pulled the strands and placed them directly on a person’s skin to create an instant, custom bandage. These bandage fibers also contained an antibiotic, which successfully inhibited bacterial growth. The researchers say that this work could open up new possibilities for future biomedical applications of nanofibers.
Source: acs.org
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