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The researchers found that Caenorhabditis elegans fed Bacillus subtilis var. natto had a significantly longer lifespan than those fed the standard diet, and further elucidated that the p38 MAPK pathway and insulin/IGF-1-like signaling pathway, which are known to be involved in innate immunity and lifespan, were involved in the lifespan-enhancing effects of Bacillus subtilis var. natto.
Professor Nakadai concluded, “For the first time, we were able to demonstrate the possibility of lifespan-extending effects of Caenorhabditis elegans through the ingestion of Bacillus subtilis var. natto. We hope that future experiments on mammals and epidemiological studies will help to realize a healthy and longer-living society if we can apply this research to humans.”
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The research results were published online in the Journal of Applied Microbiology.
Reference :
- Impacts of Bacillus subtilis var. natto on the lifespan and stress resistance of Caenorhabditis elegans – (https://academic.oup.com/jambio/article-abstract/134/4/lxad082/7134075?redirectedFrom=fulltext)
Source: Eurekalert
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